The search region determines the location of the search results and thus, in particular, the hot trends of the homepage depending on the selected country.
You can change it by clicking on Settings below the search bar. For some regions, a search language is also suggested to you.
By choosing a search region, you are setting the associated interface language. However, if you wish to set the interface language differently from the search language, just go to the Qwant settings (gear icon at the bottom right of the screen) and choose there the desired interface language. The search region will itself remain unchanged.